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- Title
Lack of renal 11 beta-hydroxysteroid dehydrogenase type 2 at birth, a targeted temporal window for neonatal glucocorticoid action in human and mice.
- Authors
Martinerie, Laetitia; Pussard, Eric; Meduri, Geri; Delezoide, Anne-Lise; Boileau, Pascal; Lombès, Marc
- Abstract
Glucocorticoid hormones play a major role in fetal organ maturation. Yet, excessive glucocorticoid exposure in utero can result in a variety of detrimental effects, such as growth retardation and increased susceptibility to the development of hypertension. To protect the fetus, maternal glucocorticoids are metabolized into inactive compounds by placental 11beta-hydroxysteroid dehydrogenase type2 (11βHSD2). This enzyme is also expressed in the kidney, where it prevents illicit occupation of the mineralocorticoid receptor by glucocorticoids. We investigated the role of renal 11βHSD2 in the control of neonatal glucocorticoid metabolism in the human and mouse.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe31949
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0031949