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- Title
Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.
- Authors
Boudreau, Luc H; Maillet, Jacques; LeBlanc, Luc M; Jean-François, Jacques; Touaibia, Mohamed; Flamand, Nicolas; Surette, Marc E
- Abstract
5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition of LT biosynthesis is a strategy for the treatment of these chronic diseases.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe31833
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0031833