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- Title
Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach.
- Authors
Doss, C George Priya; Nagasundaram, N
- Abstract
Elucidating the molecular dynamic behavior of Protein-DNA complex upon mutation is crucial in current genomics. Molecular dynamics approach reveals the changes on incorporation of variants that dictate the structure and function of Protein-DNA complexes. Deleterious mutations in APE1 protein modify the physicochemical property of amino acids that affect the protein stability and dynamic behavior. Further, these mutations disrupt the binding sites and prohibit the protein to form complexes with its interacting DNA.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe31677
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0031677