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- Title
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.
- Authors
Larsson, Pia; Ulfhammer, Erik; Magnusson, Mia; Bergh, Niklas; Lunke, Sebastian; El-Osta, Assam; Medcalf, Robert L; Svensson, Per-Arne; Karlsson, Lena; Jern, Sverker
- Abstract
Stimulated release of tissue-type plasminogen activator (t-PA) is pivotal for an intravascular fibrinolytic response and protects the circulation from occluding thrombosis. Hence, an impaired t-PA production is associated with increased risk for atherothrombotic events. A pharmacological means to stimulate the production of this enzyme may thus be desirable. We investigated if the anti-epileptic drug valproic acid (VPA) is capable of enhancing t-PA expression in vitro in vascular endothelial cells, and further examined if its histone deacetylase (HDAC)-inhibitory activity is of importance for regulating t-PA expression.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe31573
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0031573