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Title
Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells.
Authors
Zito, Christopher R; Jilaveanu, Lucia B; Anagnostou, Valsamo; Rimm, David; Bepler, Gerold; Maira, Sauveur-Michel; Hackl, Wolfgang; Camp, Robert; Kluger, Harriet M; Chao, Herta H
Abstract
We assessed expression of p85 and p110α PI3K subunits in non-small cell lung cancer (NSCLC) specimens and the association with mTOR expression, and studied effects of targeting the PI3K/AKT/mTOR pathway in NSCLC cell lines.