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- Title
Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection.
- Authors
Sasson, Sarah C; Zaunders, John J; Seddiki, Nabila; Bailey, Michelle; McBride, Kristin; Koelsch, Kersten K; Merlin, Kate M; Smith, Don E; Cooper, David A; Kelleher, Anthony D
- Abstract
HIV infection is associated with distortion of T-cell homeostasis and the IL-7/IL7R axis. Progressive infection results in loss of CD127+132- and gains in CD127-132+ CD4+ and CD8+ T-cells. We investigated the correlates of loss of CD127 from the T-cell surface to understand mechanisms underlying this homeostatic dysregulation.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe31148
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0031148