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- Title
Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer.
- Authors
van der Horst, Paul H; Wang, Yongyi; Vandenput, Ingrid; Kühne, Liesbeth C; Ewing, Patricia C; van Ijcken, Wilfred F J; van der Zee, Marten; Amant, Frederic; Burger, Curt W; Blok, Leen J
- Abstract
Every year approximately 74,000 women die of endometrial cancer, mainly due to recurrent or metastatic disease. The presence of tumor infiltrating lymphocytes (TILs) as well as progesterone receptor (PR) positivity has been correlated with improved prognosis. This study describes two mechanisms by which progesterone inhibits metastatic spread of endometrial cancer: by stimulating T-cell infiltration and by inhibiting epithelial-to-mesenchymal cell transition (EMT).
- Publication
PloS one, 2012, Vol 7, Issue 1, pe30840
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030840