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- Title
Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants.
- Authors
Shanmugam, Arulkumaran; Rajoria, Shilpi; George, Andrea L; Mittelman, Abraham; Suriano, Robert; Tiwari, Raj K
- Abstract
Adjuvants serve as catalysts of the innate immune response by initiating a localized site of inflammation that is mitigated by the interactions between antigens and toll like receptor (TLR) proteins. Currently, the majority of vaccines are formulated with aluminum based adjuvants, which are associated with various side effects. In an effort to develop a new class of adjuvants, agonists of TLR proteins, such as bacterial products, would be natural candidates. Lipopolysaccharide (LPS), a major structural component of gram negative bacteria cell walls, induces the systemic inflammation observed in septic shock by interacting with TLR-4. The use of synthetic peptides of LPS or TLR-4 agonists, which mimic the interaction between TLR-4 and LPS, can potentially regulate cellular signal transduction pathways such that a localized inflammatory response is achieved similar to that generated by adjuvants.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe30839
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030839