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- Title
LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.
- Authors
Bieghs, Veerle; Van Gorp, Patrick J; Wouters, Kristiaan; Hendrikx, Tim; Gijbels, Marion J; van Bilsen, Marc; Bakker, Jaap; Binder, Christoph J; Lütjohann, Dieter; Staels, Bart; Hofker, Marten H; Shiri-Sverdlov, Ronit
- Abstract
Non-alcoholic steatohepatitis (NASH) involves steatosis combined with inflammation, which can progress into fibrosis and cirrhosis. Exploring the molecular mechanisms of NASH is highly dependent on the availability of animal models. Currently, the most commonly used animal models for NASH imitate particularly late stages of human disease. Thus, there is a need for an animal model that can be used for investigating the factors that potentiate the inflammatory response within NASH. We have previously shown that 7-day high-fat-high-cholesterol (HFC) feeding induces steatosis and inflammation in both APOE2ki and Ldlr(-/-) mice. However, it is not known whether the early inflammatory response observed in these mice will sustain over time and lead to liver damage. We hypothesized that the inflammatory response in both models is sufficient to induce liver damage over time.
- Publication
PloS one, 2012, Vol 7, Issue 1, pe30668
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030668