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- Title
Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
- Authors
Belda, Eugeni; Silva, Francisco J; Peretó, Juli; Moya, Andrés
- Abstract
Genome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of ecological association with the host. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, represents one of the few complete genomes available of a bacterium at the initial stages of this process. In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius.
- Publication
PloS one, 2012, Vol 7, Issue 1, pe30652
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030652