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- Title
Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults.
- Authors
Tyrka, Audrey R; Price, Lawrence H; Marsit, Carmen; Walters, Oakland C; Carpenter, Linda L
- Abstract
A history of early adverse experiences is an important risk factor for adult psychopathology. Changes in stress sensitivity and functioning of the hypothalamic-pituitary-adrenal (HPA) axis may underlie the association between stress and risk for psychiatric disorders. Preclinical work in rodents has linked low levels of maternal care to increased methylation of the promoter region of the glucocorticoid receptor (GR) gene, as well as to exaggerated hormonal and behavioral responses to stress. Recent studies have begun to examine whether early-life stress leads to epigenetic modifications of the GR gene in humans.
- Publication
PloS one, 2012, Vol 7, Issue 1, pe30148
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030148