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- Title
Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.
- Authors
Lataillade, Max; Chiarella, Jennifer; Yang, Rong; DeGrosky, Michelle; Uy, Jonathan; Seekins, Daniel; Simen, Birgitte; St John, Elizabeth; Moreno, Elizabeth; Kozal, Michael
- Abstract
It is unknown whether HIV-positive patients experiencing virologic failure (VF) on boosted-PI (PI/r) regimens without drug resistant mutations (DRM) by standard genotyping harbor low-level PI resistant variants. CASTLE compared the efficacy of atazanavir/ritonavir (ATV/r) with lopinavir/ritonavir (LPV/r), each in combination with TVD in ARV-naïve subjects.
- Publication
PloS one, 2012, Vol 7, Issue 2, pe30118
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0030118