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- Title
Characterization of the endothelial cell cytoskeleton following HLA class I ligation.
- Authors
Ziegler, Mary E; Souda, Puneet; Jin, Yi-Ping; Whitelegge, Julian P; Reed, Elaine F
- Abstract
Vascular endothelial cells (ECs) are a target of antibody-mediated allograft rejection. In vitro, when the HLA class I molecules on the surface of ECs are ligated by anti-HLA class I antibodies, cell proliferation and survival pathways are activated and this is thought to contribute to the development of antibody-mediated rejection. Crosslinking of HLA class I molecules by anti-HLA antibodies also triggers reorganization of the cytoskeleton, which induces the formation of F-actin stress fibers. HLA class I induced stress fiber formation is not well understood.
- Publication
PloS one, 2012, Vol 7, Issue 1, pe29472
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0029472