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- Title
General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain.
- Authors
Tanaka, Tomoharu; Kai, Shinichi; Koyama, Tomohiro; Daijo, Hiroki; Adachi, Takehiko; Fukuda, Kazuhiko; Hirota, Kiichi
- Abstract
Erythropoietin (EPO), originally identified as a hematopoietic growth factor produced in the kidney and fetal liver, is also endogenously expressed in the central nervous system (CNS). EPO in the CNS, mainly produced in astrocytes, is induced under hypoxic conditions in a hypoxia-inducible factor (HIF)-dependent manner and plays a dominant role in neuroprotection and neurogenesis. We investigated the effect of general anesthetics on EPO expression in the mouse brain and primary cultured astrocytes.
- Publication
PloS one, 2011, Vol 6, Issue 12, pe29378
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0029378