We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.
- Authors
Goel, Namni; Banks, Siobhan; Lin, Ling; Mignot, Emmanuel; Dinges, David F
- Abstract
The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD), a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis.
- Publication
PloS one, 2011, Vol 6, Issue 12, pe29283
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0029283