We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.
- Authors
Hernesniemi, Jussi A; Seppälä, Ilkka; Lyytikäinen, Leo-Pekka; Mononen, Nina; Oksala, Niku; Hutri-Kähönen, Nina; Juonala, Markus; Taittonen, Leena; Smith, Erin N; Schork, Nicholas J; Chen, Wei; Srinivasan, Sathanur R; Berenson, Gerald S; Murray, Sarah S; Laitinen, Tomi; Jula, Antti; Kettunen, Johannes; Ripatti, Samuli; Laaksonen, Reijo; Viikari, Jorma; Kähönen, Mika; Raitakari, Olli T; Lehtimäki, Terho
- Abstract
Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve already known associations and discovered thirteen new SNPs associating with CAD. We examined whether the genetic profiling of these variants improves prediction of subclinical atherosclerosis--i.e., carotid intima-media thickness (CIMT) and carotid artery elasticity (CAE)--beyond classical risk factors.
- Publication
PloS one, 2012, Vol 7, Issue 1, pe28931
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0028931