We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
- Authors
Lingappa, Jairam R; Petrovski, Slavé; Kahle, Erin; Fellay, Jacques; Shianna, Kevin; McElrath, M Juliana; Thomas, Katherine K; Baeten, Jared M; Celum, Connie; Wald, Anna; de Bruyn, Guy; Mullins, James I; Nakku-Joloba, Edith; Farquhar, Carey; Essex, Max; Donnell, Deborah; Kiarie, James; Haynes, Bart; Goldstein, David; Partners in Prevention HSV/HIV Transmission Study Team
- Abstract
Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use.
- Publication
PloS one, 2011, Vol 6, Issue 12, pe28632
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0028632