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- Title
Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients.
- Authors
Alam, Hunain; Gangadaran, Prakash; Bhate, Amruta V; Chaukar, Devendra A; Sawant, Sharada S; Tiwari, Richa; Bobade, Jyoti; Kannan, Sadhana; D'cruz, Anil K; Kane, Shubhada; Vaidya, Milind M
- Abstract
Keratins are cytoplasmic intermediate filament proteins expressed in tissue specific and differentiation dependent manner. Keratins 8 and 18 (K8 and K18) are predominantly expressed in simple epithelial tissues and perform both mechanical and regulatory functions. Aberrant expression of K8 and K18 is associated with neoplastic progression, invasion and poor prognosis in human oral squamous cell carcinomas (OSCCs). K8 and K18 undergo several post-translational modifications including phosphorylation, which are known to regulate their functions in various cellular processes. Although, K8 and K18 phosphorylation is known to regulate cell cycle, cell growth and apoptosis, its significance in cell migration and/or neoplastic progression is largely unknown. In the present study we have investigated the role of K8 phosphorylation in cell migration and/or neoplastic progression in OSCC.
- Publication
PloS one, 2011, Vol 6, Issue 11, pe27767
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0027767