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Title
Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
Authors
Sperka, Tobias; Geissler, Katja J; Merkel, Ulrike; Scholl, Ingmar; Rubio, Ignacio; Herrlich, Peter; Morrison, Helen L
Abstract
Receptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras.