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- Title
A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.
- Authors
Xavier, Ana C; Edwards, Holly; Dombkowski, Alan A; Balci, Tugce B; Berman, Jason N; Dellaire, Graham; Xie, Chengzhi; Buck, Steven A; Matherly, Larry H; Ge, Yubin; Taub, Jeffrey W
- Abstract
Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GATA1 or due to a unique function of GATA1s.
- Publication
PloS one, 2011, Vol 6, Issue 11, pe27486
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0027486