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- Title
Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European Caucasians.
- Authors
Ebner, Sabine; Lang, Roland; Mueller, Edith E; Eder, Waltraud; Oeller, Michaela; Moser, Alexandra; Koller, Josef; Paulweber, Bernhard; Mayr, Johannes A; Sperl, Wolfgang; Kofler, Barbara
- Abstract
Because mitochondria play an essential role in energy metabolism, generation of reactive oxygen species (ROS), and apoptosis, sequence variation in the mitochondrial genome has been postulated to be a contributing factor to the etiology of multifactorial age-related diseases, including cancer. The aim of the present study was to compare the frequencies of mitochondrial DNA (mtDNA) haplogroups as well as control region (CR) polymorphisms of patients with malignant melanoma (n = 351) versus those of healthy controls (n = 1598) in Middle Europe.
- Publication
PloS one, 2011, Vol 6, Issue 12, pe27192
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0027192