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- Title
Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.
- Authors
Palus, Sandra; Schur, Robert; Akashi, Yoshihiro J; Bockmeyer, Barbara; Datta, Rakesh; Halem, Heather; Dong, Jesse; Culler, Michael D; Adams, Volker; Anker, Stefan D; Springer, Jochen
- Abstract
Cardiac cachexia is a serious complication of chronic heart failure with a prevalence of 10-16% and poor prognosis. There are no current therapy options for cardiac cachexia. Ghrelin is the natural ligand for the GHS-1a-receptor and a potential target for conditions associated with cachexia. Ghrelin has been shown to increase weight in several species. The GHS-1a-receptor is not only found in the brain, but also in other tissues, including the myocardium. Human clinical trials with native ghrelin in cardiac cachexia demonstrated increases in appetite, weight and cardiac output.
- Publication
PloS one, 2011, Vol 6, Issue 11, pe26865
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026865