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- Title
Development of a middle cerebral artery occlusion model in the nonhuman primate and a safety study of i.v. infusion of human mesenchymal stem cells.
- Authors
Sasaki, Masanori; Honmou, Osamu; Radtke, Christine; Kocsis, Jeffery D
- Abstract
Most experimental stroke research is carried out in rodents, but given differences between rodents and human, nonhuman primate (NHP) models may provide a valuable tool to study therapeutic interventions. The authors developed a surgical method for transient occlusion of the M1 branch of middle cerebral artery (MCA) in the African green monkey to evaluate safety aspects of intravenous infusion of mesenchymal stem cells (hMSCs) derived from human bone marrow.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26577
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026577