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- Title
Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro.
- Authors
Abdel-Motal, Ussama M; Sarkis, Phuong T N; Han, Thomas; Pudney, Jeffery; Anderson, Deborah J; Zhu, Quan; Marasco, Wayne A
- Abstract
Although cervico-vaginal epithelial cells of the female lower genital tract provide the initial defense system against HIV-1 infection, the protection is sometimes incomplete. Thus, enhancing anti-HIV-1 humoral immunity at the mucosal cell surface by local expression of anti-HIV-1 broadly neutralizing antibodies (BnAb) that block HIV-1 entry would provide an important new intervention that could slow the spread of HIV/AIDS.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26473
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026473