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- Title
Hippocampal CA3 transcriptome signature correlates with initial precipitating injury in refractory mesial temporal lobe epilepsy.
- Authors
Bando, Silvia Y; Alegro, Maryana C; Amaro, Edson, Jr; Silva, Alexandre V; Castro, Luiz H M; Wen, Hung-Tzu; Lima, Leandro de A; Brentani, Helena; Moreira-Filho, Carlos Alberto
- Abstract
Prolonged febrile seizures constitute an initial precipitating injury (IPI) commonly associated with refractory mesial temporal lobe epilepsy (RMTLE). In order to investigate IPI influence on the transcriptional phenotype underlying RMTLE we comparatively analyzed the transcriptomic signatures of CA3 explants surgically obtained from RMTLE patients with (FS) or without (NFS) febrile seizure history. Texture analyses on MRI images of dentate gyrus were conducted in a subset of surgically removed sclerotic hippocampi for identifying IPI-associated histo-radiological alterations.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26268
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026268