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- Title
Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study.
- Authors
Bender, Nicole; Allemann, Noëmi; Marek, Diana; Vollenweider, Peter; Waeber, Gérard; Mooser, Vincent; Egger, Matthias; Bochud, Murielle
- Abstract
Three non-synonymous single nucleotide polymorphisms (Q223R, K109R and K656N) of the leptin receptor gene (LEPR) have been tested for association with obesity-related outcomes in multiple studies, showing inconclusive results. We performed a systematic review and meta-analysis on the association of the three LEPR variants with BMI. In addition, we analysed 15 SNPs within the LEPR gene in the CoLaus study, assessing the interaction of the variants with sex.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26157
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026157