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- Title
Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE.
- Authors
Lammers, Bart; Zhao, Ying; Hoekstra, Menno; Hildebrand, Reeni B; Ye, Dan; Meurs, Illiana; Van Berkel, Theo J C; Van Eck, Miranda
- Abstract
ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo) A-I. In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26095
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026095