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- Title
High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.
- Authors
Maharjan, Anu S; Pilling, Darrell; Gomer, Richard H
- Abstract
Following tissue injury, monocytes can enter the tissue and differentiate into fibroblast-like cells called fibrocytes, but little is known about what regulates this differentiation. Extracellular matrix contains high molecular weight hyaluronic acid (HMWHA; ∼2×10(6) Da). During injury, HMWHA breaks down to low molecular weight hyaluronic acid (LMWHA; ∼0.8-8×10(5) Da).
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26078
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026078