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- Title
Rapid high yield production of different glycoforms of Ebola virus monoclonal antibody.
- Authors
Castilho, Alexandra; Bohorova, Natasha; Grass, Josephine; Bohorov, Ognian; Zeitlin, Larry; Whaley, Kevin; Altmann, Friedrich; Steinkellner, Herta
- Abstract
Fc-glycosylation of monoclonal antibodies (mAbs) has profound implications on the Fc-mediated effector functions. Alteration of this glycosylation may affect the efficiency of an antibody. However, difficulties in the production of mAbs with homogeneous N-glycosylation profiles in sufficient amounts hamper investigations of the potential biological impact of different glycan residues.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe26040
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0026040