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- Title
Genetic Variations in Plasma Circulating DNA of HBVRelated Hepatocellular Carcinoma Patients Predict Recurrence after Liver Transplantation.
- Authors
Jie Hu; Zheng Wang; Jia Fan; Zhi Dai; Yi-Feng He; Shuang-Jian Qiu; Xiao-Wu Huang; Jian Sun; Yong-Sheng Xiao; Kang Song; Ying-Hong Shi; Qi-Man Sun; Xin-Rong Yang; Guo-Ming Shi; Lei Yu; Guo-Huan Yang; Zhen-Bin Ding; Qiang Gao; Zhao-You Tang; Jian Zhou
- Abstract
Background: Recurrence prediction of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) present a great challenge because of a lack of biomarkers. Genetic variations play an important role in tumor development and metastasis. Methods: Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorphism were selected, and their prognostic value was assessed and validated in two independent cohorts of HCC patients (N = 102 and N = 77), using pretransplant plasma circulating DNA. Prognostic significance was assessed by Kaplan-Meier survival estimates and log-rank tests. Multivariate analyses were performed to evaluate prognosis-related factors. Results: rs894151 and rs12438080 were significantly associated with recurrence (P = .003 and P = .004, respectively). Multivariate analyses demonstrated that the co-index of the 2 SNPs was an independent prognostic factor for recurrence (P = .040). Similar results were obtained in the third cohort (N = 77). Furthermore, for HCC patients (all the 3 cohorts) exceeding Milan criteria, the co-index was a prognostic factor for recurrence and survival (P<.001 and P = .002, respectively). Conclusions: Our study demonstrated first that genetic variations of rs894151 and rs12438080 in pretransplant plasma circulating DNA are promising prognostic markers for tumor recurrence in HCC patients undergoing LT and identify a subgroup of patients who, despite having HCC exceeding Milan criteria, have a low risk of post-transplant recurrence.
- Publication
PLoS ONE, 2011, Vol 6, Issue 10, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0026003