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- Title
Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
- Authors
Yahata, Naoki; Asai, Masashi; Kitaoka, Shiho; Takahashi, Kazutoshi; Asaka, Isao; Hioki, Hiroyuki; Kaneko, Takeshi; Maruyama, Kei; Saido, Takaomi C; Nakahata, Tatsutoshi; Asada, Takashi; Yamanaka, Shinya; Iwata, Nobuhisa; Inoue, Haruhisa
- Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex)-mediated sequential cleavage. Induced pluripotent stem (iPS) cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe25788
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025788