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- Title
IL28B alleles exert an additive dose effect when applied to HCV-HIV coinfected persons undergoing peginterferon and ribavirin therapy.
- Authors
Dayyeh, Barham K Abu; Gupta, Namrata; Sherman, Kenneth E; de Bakker, Paul I W; Chung, Raymond T; Aids Clinical Trials Group A5178 Study Team
- Abstract
Genetic studies have demonstrated a strong association between single nucleotide polymorphisms (SNPs) at IL28B and response to treatment with peginterferon (PEG) and ribavirin (RBV) in HCV monoinfected persons. We sought to test these associations in a prospective PEG / weight based ribavirin (WBR) treatment trial (ACTG A5178) (National Institution of Health registration number NCT00078403) in persons with HCV-HIV coinfection, and to develop a prediction score.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe25753
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025753