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- Title
Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
- Authors
Aster, Jon C; Bodnar, Nick; Xu, Lanwei; Karnell, Fredrick; Milholland, John M; Maillard, Ivan; Histen, Gavin; Nam, Yunsun; Blacklow, Stephen C; Pear, Warren S
- Abstract
The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell acute lymphoblastic leukemia/lymphoma (T-ALL), and maintain T-ALL cell growth and survival.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe25645
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025645