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- Title
Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL.
- Authors
Ding, Yinyuan; Zhang, Ling; Wang, Yuhui; Huang, Wei; Tang, Yin; Bai, Lu; Ross, Colin J D; Hayden, Michael R; Liu, George
- Abstract
Macrophage-derived lipoprotein lipase (LPL) has been shown uniformly to promote atherosclerotic lesion formation while the extent to which it affects plasma lipid and lipoprotein levels varies in wild-type and hypercholesterolemic mice. It is known that high levels of LPL in the bulk of adipose tissue and skeletal muscle would certainly mask the contribution of macrophage LPL to metabolism of plasma lipoprotein. Therefore, we chose LPL deficient (LPL⁻/⁻) mice with severe hypertriglyceridemia as an alternative model to assess the role of macrophage LPL in plasma lipoprotein metabolism via bone marrow transplant, through which LPL will be produced mainly by hematopoietic cell-derived macrophages.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe25620
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025620