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- Title
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
- Authors
Deraz, Elsayed Mohamed; Kudo, Yasusei; Yoshida, Maki; Obayashi, Mariko; Tsunematsu, Takaaki; Tani, Hirotaka; Siriwardena, Samadarani B S M; Keikhaee, Mohammad Reza; Qi, Guangying; Iizuka, Shinji; Ogawa, Ikuko; Campisi, Giuseppina; Lo Muzio, Lorenzo; Abiko, Yoshimitsu; Kikuchi, Akira; Takata, Takashi
- Abstract
Periostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data sets. In this study, we investigated the roles of MMP-10 in the invasion of HNSCC.
- Publication
PloS one, 2011, Vol 6, Issue 10, pe25438
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025438