We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
- Authors
Weisberg, Ellen; Ray, Arghya; Nelson, Erik; Adamia, Sophia; Barrett, Rosemary; Sattler, Martin; Zhang, Chengsheng; Daley, John F; Frank, David; Fox, Edward; Griffin, James D
- Abstract
Clinical responses achieved with FLT3 kinase inhibitors in acute myeloid leukemia (AML) are typically transient and partial. Thus, there is a need for identification of molecular mechanisms of clinical resistance to these drugs. In response, we characterized MOLM13 AML cell lines made resistant to two structurally-independent FLT3 inhibitors.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe25351
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025351