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- Title
Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models.
- Authors
Moroni, Maria; Lombardini, Eric; Salber, Rudolph; Kazemzedeh, Mehdi; Nagy, Vitaly; Olsen, Cara; Whitnall, Mark H
- Abstract
The animal efficacy rule addressing development of drugs for selected disease categories has pointed out the need to develop alternative large animal models. Based on this rule, the pathophysiology of the disease in the animal model must be well characterized and must reflect that in humans. So far, manifestations of the acute radiation syndrome (ARS) have been extensively studied only in two large animal models, the non-human primate (NHP) and the canine. We are evaluating the suitability of the minipig as an additional large animal model for development of radiation countermeasures. We have previously shown that the Gottingen minipig manifests hematopoietic ARS phases and symptoms similar to those observed in canines, NHPs, and humans.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe25210
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025210