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- Title
TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers.
- Authors
Shima, Kaori; Morikawa, Teppei; Yamauchi, Mai; Kuchiba, Aya; Imamura, Yu; Liao, Xiaoyun; Meyerhardt, Jeffrey A; Fuchs, Charles S; Ogino, Shuji
- Abstract
Mononucleotide tracts in the coding regions of the TGFBR2 and BAX genes are commonly mutated in microsatellite instability-high (MSI-high) colon cancers. The receptor TGFBR2 plays an important role in the TGFB1 (transforming growth factor-β, TGF-β) signaling pathway, and BAX plays a key role in apoptosis. However, a role of TGFBR2 or BAX mononucleotide mutation in colorectal cancer as a prognostic biomarker remains uncertain.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe25062
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0025062