Title

Protective Role of Heme Oxygenase-1 in Listeria monocytogenes-Induced Abortion.

Authors

Tachibana, Masato; Hashino, Masanori; Nishida, Takashi; Shimizu, Takashi; Watarai, Masahisa

Abstract

It is well-known fact that various pathogens, including bacteria, virus, and protozoa, induce abortion in humans and animals. However the mechanisms of infectious abortion are little known. In this study, we demonstrated that Listeria monocytogenes infection in trophoblast giant cells decreased heme oxygenase (HO)-1 and B-cell lymphoma-extra large (Bcl- XL) expression, and that their overexpression inhibited cell death induced by the infection. Furthermore, HO-1 and Bcl-XL expression levels were also decreased by L. monocytogenes in pregnant mice. Treatment with cobalt protoporphyrin, which is known to induce HO-1, inhibited infectious abortion. Taken together, our study indicates that L. monocytogenes infection decreases HO-1 and Bcl-XL expression and induces cell death in placenta, leading to infectious abortion.

Subjects

HEME oxygenase; ABORTION in animals; LISTERIA monocytogenes; GENE expression; PROTOPORPHYRINS; LABORATORY mice; B cells; TROPHOBLAST

Publication

PLoS ONE, 2011, Vol 6, Issue 9, p1

ISSN

1932-6203

Publication type

Academic Journal

DOI

10.1371/journal.pone.0025046