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- Title
MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay.
- Authors
Veidal, Sanne Skovgård; Karsdal, Morten Asser; Vassiliadis, Efstathios; Nawrocki, Arkadiusz; Larsen, Martin Røssel; Nguyen, Quoc Hai Trieu; Hägglund, Per; Luo, Yunyun; Zheng, Qinlong; Vainer, Ben; Leeming, Diana Julie
- Abstract
During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe24753
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0024753