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- Title
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.
- Authors
Zou, Zhongcheng; Chastain, Ashley; Moir, Susan; Ford, Jennifer; Trandem, Kathryn; Martinelli, Elena; Cicala, Claudia; Crocker, Paul; Arthos, James; Sun, Peter D
- Abstract
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4), variations in infection are common within both R5- and X4-tropic viruses, indicating additional factors may contribute to viral tropism.
- Publication
PloS one, 2011, Vol 6, Issue 9, pe24559
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0024559