We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole.
- Authors
Choi, Hye Joung; Fukui, Masayuki; Zhu, Bao Ting
- Abstract
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic microtubule inhibitor, results in strong up-regulation of cyclin B1 and Cdc2 levels, and their increases are required for the development of mitotic prometaphase arrest and characteristic phenotypes.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe24312
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0024312