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- Title
A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress.
- Authors
Wu, Xiangli; Wang, Xiuhong; Drlica, Karl; Zhao, Xilin
- Abstract
Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules protect from stress, while others argue that they amplify lethal stress and lead to programmed cell death. To avoid ambiguity arising from the presence of multiple TA modules in E. coli, the effect of the sole type-2 toxin-antitoxin module of Bacillus subtilis was examined for several types of lethal stress.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23909
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023909