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- Title
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.
- Authors
Talbot, Anne-Laure; Bullock, Grant C; Delehanty, Lorrie L; Sattler, Martin; Zhao, Zhizhuang Joe; Goldfarb, Adam N
- Abstract
Erythroid development requires the action of erythropoietin (EPO) on committed progenitors to match red cell output to demand. In this process, iron acts as a critical cofactor, with iron deficiency blunting EPO-responsiveness of erythroid progenitors. Aconitase enzymes have recently been identified as possible signal integration elements that couple erythropoiesis with iron availability. In the current study, a regulatory role for aconitase during erythropoiesis was ascertained using a direct inhibitory strategy.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23850
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023850