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- Title
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression.
- Authors
Uosaki, Hideki; Fukushima, Hiroyuki; Takeuchi, Ayako; Matsuoka, Satoshi; Nakatsuji, Norio; Yamanaka, Shinya; Yamashita, Jun K
- Abstract
Human embryonic and induced pluripotent stem cells (hESCs/hiPSCs) are promising cell sources for cardiac regenerative medicine. To realize hESC/hiPSC-based cardiac cell therapy, efficient induction, purification, and transplantation methods for cardiomyocytes are required. Though marker gene transduction or fluorescent-based purification methods have been reported, fast, efficient and scalable purification methods with no genetic modification are essential for clinical purpose but have not yet been established. In this study, we attempted to identify cell surface markers for cardiomyocytes derived from hESC/hiPSCs.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23657
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023657