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- Title
Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production.
- Authors
Matsumoto, Mitsuharu; Kurihara, Shin; Kibe, Ryoko; Ashida, Hisashi; Benno, Yoshimi
- Abstract
Chronic low-grade inflammation is recognized as an important factor contributing to senescence and age-related diseases. In mammals, levels of polyamines (PAs) decrease during the ageing process; PAs are known to decrease systemic inflammation by inhibiting inflammatory cytokine synthesis in macrophages. Reductions in intestinal luminal PAs levels have been associated with intestinal barrier dysfunction. The probiotic strain Bifidobacterium animalis subsp. lactis LKM512 is known to increase intestinal luminal PA concentrations.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23652
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023652