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- Title
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma.
- Authors
Baldi, Alfonso; Piccolo, Maria Teresa; Boccellino, Maria Rosaria; Donizetti, Aldo; Cardillo, Irene; La Porta, Raffaele; Quagliuolo, Lucio; Spugnini, Enrico P; Cordero, Francesca; Citro, Gennaro; Menegozzo, Massimo; Calogero, Raffaele A; Crispi, Stefania
- Abstract
Malignant mesothelioma (MM) is a rare, highly aggressive tumor, associated to asbestos exposure. To date no chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be developed. We have previously shown in vivo that piroxicam/cisplatin combined treatment in MM, specifically acts on cell cycle regulation triggering apoptosis, with survival increase.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23569
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023569