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- Title
Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis.
- Authors
Saber, Tajvur; Veale, Douglas J; Balogh, Emese; McCormick, Jennifer; NicAnUltaigh, Sinead; Connolly, Mary; Fearon, Ursula
- Abstract
Angiogenesis is a critical early event in inflammatory arthritis, facilitating leukocyte migration into the synovium resulting in invasion and destruction of articular cartilage and bone. This study investigates the effect of TLR2 on angiogenesis, EC adhesion and invasion using microvascular endothelial cells and RA whole tissue synovial explants ex-vivo.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe23540
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0023540