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- Title
HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.
- Authors
Mangino, Giorgio; Percario, Zulema A; Fiorucci, Gianna; Vaccari, Gabriele; Acconcia, Filippo; Chiarabelli, Cristiano; Leone, Stefano; Noto, Alessia; Horenkamp, Florian A; Manrique, Santiago; Romeo, Giovanna; Polticelli, Fabio; Geyer, Matthias; Affabris, Elisabetta
- Abstract
HIV-1 Nef is a virulence factor that plays multiple roles during HIV replication. Recently, it has been described that Nef intersects the CD40 signalling in macrophages, leading to modification in the pattern of secreted factors that appear able to recruit, activate and render T lymphocytes susceptible to HIV infection. The engagement of CD40 by CD40L induces the activation of different signalling cascades that require the recruitment of specific tumor necrosis factor receptor-associated factors (i.e. TRAFs). We hypothesized that TRAFs might be involved in the rapid activation of NF-κB, MAPKs and IRF-3 that were previously described in Nef-treated macrophages to induce the synthesis and secretion of proinflammatory cytokines, chemokines and IFNβ to activate STAT1, -2 and -3.
- Publication
PloS one, 2011, Vol 6, Issue 8, pe22982
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0022982