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- Title
Biologic phenotyping of the human small airway epithelial response to cigarette smoking.
- Authors
Tilley, Ann E; O'Connor, Timothy P; Hackett, Neil R; Strulovici-Barel, Yael; Salit, Jacqueline; Amoroso, Nancy; Zhou, Xi Kathy; Raman, Tina; Omberg, Larsson; Clark, Andrew; Mezey, Jason; Crystal, Ronald G
- Abstract
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biologic phenotyping of the smoking response, and that a subset of healthy smokers would have a "COPD-like" SAE transcriptome.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe22798
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0022798